# Shugoshin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173507](https://www.wikidata.org/wiki/Q21173507)  
**Source**: https://4ort.xyz/entity/shugoshin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q5FBB7)
3. Q20641742
4. [sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
5. [PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
6. [Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
7. [Heterochromatin links to centromeric protection by recruiting shugoshin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
8. [Shugoshin collaborates with protein phosphatase 2A to protect cohesin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
9. [Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
10. [Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
11. [Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
12. [Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
13. [Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
14. [Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
15. [Bod1 regulates protein phosphatase 2A at mitotic kinetochores](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
17. [Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
18. [Phospho-H2A and Cohesin Specify Distinct Tension-Regulated Sgo1 Pools at Kinetochores and Inner Centromeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
19. [Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
20. [Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
21. [A nucleolar protein RRS1 contributes to chromosome congression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5FBB7)
22. Ensembl Release 99