# SHC adaptor protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116165](https://www.wikidata.org/wiki/Q21116165)  
**Source**: https://4ort.xyz/entity/shc-adaptor-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29353)
3. Q20641742
4. [Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
5. [Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
6. [A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
7. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
8. [TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
9. [EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29353&geneProductId=UniProtKB:P29353)
12. [Temporal regulation of EGF signalling networks by the scaffold protein Shc1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
13. [The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
14. [Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
15. [Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
16. [Copine-III interacts with ErbB2 and promotes tumor cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
17. [Shc and CEACAM1 Interact to Regulate the Mitogenic Action of Insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
18. [Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
19. [A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
20. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
21. [An alternative to phosphotyrosine-containing motifs for binding to an SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
22. [HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
23. [Structure homology and interaction redundancy for discovering virus-host protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
24. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
25. [Threshold-controlled ubiquitination of the EGFR directs receptor fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
26. [The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
27. [Novel peptide inhibitors for Grb2 SH2 domain and their detection by surface plasmon resonance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
28. [Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
29. [Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
30. [The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
31. [Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
32. [Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
33. [Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
34. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
35. [The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
36. [Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
37. [SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
38. [The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
39. [Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
40. [Charting the molecular network of the drug target Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
41. [Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
42. [The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
43. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
44. [Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
45. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
46. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
47. [Charting the molecular links between driver and susceptibility genes in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
48. [Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
49. [Comparative analysis of the signaling capabilities of the insulin receptor-related receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)
50. [A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29353)