# SHC adaptor protein 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559554](https://www.wikidata.org/wiki/Q28559554)  
**Source**: https://4ort.xyz/entity/shc-adaptor-protein-1-q28559554


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q5M824)
3. Q20641742
4. [Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
5. [Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
6. [Shc and CEACAM1 Interact to Regulate the Mitogenic Action of Insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
7. [Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
8. [The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
9. [Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
12. [Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
13. [ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
14. [Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
15. [Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
16. [Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
17. [p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
18. [p66Shc regulates renal vascular tone in hypertension-induced nephropathy.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
19. [Effects of age on elements of insulin-signaling pathway in central nervous system of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
20. [Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
21. [Distinct signaling functions for Shc isoforms in the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
22. [Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
23. [Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
24. [ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
25. [Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
26. [P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
27. [Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5M824)
28. ensembl Release 106