# SHANK associated RH domain interactor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130805](https://www.wikidata.org/wiki/Q21130805)  
**Source**: https://4ort.xyz/entity/shank-associated-rh-domain-interactor-q21130805


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9H0F6)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
5. [Linear ubiquitination prevents inflammation and regulates immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
6. [SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
7. [SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
8. [A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
9. [Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
10. [Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
11. [A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
12. [SHARPIN is an endogenous inhibitor of β1-integrin activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
13. [Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
14. [Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
15. [Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
17. [Molecular Basis and Regulation of OTULIN-LUBAC Interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
18. [SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
19. [Linear ubiquitination prevents inflammation and regulates immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
20. [The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
21. [SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
22. [Newly identified tumor-associated role of human Sharpin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
23. [The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
24. [Molecular Basis and Regulation of OTULIN-LUBAC Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H0F6)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H0F6&geneProductId=UniProtKB:Q9H0F6)
26. Ensembl Release 99