# SH2 domain containing 1A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115282](https://www.wikidata.org/wiki/Q21115282)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SLAM-associated_protein)  
**Source**: https://4ort.xyz/entity/sh2-domain-containing-1a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60880)
3. Q20641742
4. [Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
5. [Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
6. [Fine specificity and molecular competition in SLAM family receptor signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
7. [Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
8. [Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
9. [SAP couples Fyn to SLAM immune receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
10. [The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
11. [SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
12. [The Adaptor Protein SAP Directly Associates with CD3ζ Chain and Regulates T Cell Receptor Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
13. [A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
15. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
16. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
17. [NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
18. [A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
19. [NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
20. [CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
21. [Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
22. [Disease-causing SAP mutants are defective in ligand binding and protein folding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
23. [Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60880)
25. Ensembl Release 99