# Sestrin 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21125178](https://www.wikidata.org/wiki/Q21125178)  
**Source**: https://4ort.xyz/entity/sestrin-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P58004)
3. Q20641742
4. [p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
5. [The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
6. [Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
7. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
8. [SZT2 dictates GATOR control of mTORC1 signalling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
9. [Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
10. [Sestrin2 is a leucine sensor for the mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
11. [RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
12. [Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
13. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
14. [Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
15. [Sestrin2 is a leucine sensor for the mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
16. [Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
17. [Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
19. [Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
22. [Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
23. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
24. [Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
25. [Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
26. [Hepatoprotective role of Sestrin2 against chronic ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
27. [p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
28. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58004&geneProductId=UniProtKB:P58004)
29. [Hepatoprotective role of Sestrin2 against chronic ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58004)
30. Ensembl Release 99