# Sestrin 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21988557](https://www.wikidata.org/wiki/Q21988557)  
**Source**: https://4ort.xyz/entity/sestrin-2-q21988557


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P58043)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
5. [p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
6. [Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
9. [Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043)
10. [Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
11. [Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
12. [Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
13. [Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043)
14. [Hepatoprotective role of Sestrin2 against chronic ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P58043&geneProductId=UniProtKB:P58043)
15. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
16. [Hepatoprotective role of Sestrin2 against chronic ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58043)
17. ensembl Release 106