# Sestrin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21125185](https://www.wikidata.org/wiki/Q21125185)  
**Source**: https://4ort.xyz/entity/sestrin-1-q21125185


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y6P5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
5. [Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
6. [Sestrin2 is a leucine sensor for the mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6P5&geneProductId=UniProtKB:Q9Y6P5)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
8. [Sestrin2 is a leucine sensor for the mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6P5&geneProductId=UniProtKB:Q9Y6P5)
10. [Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6P5&geneProductId=UniProtKB:Q9Y6P5)
11. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6P5&geneProductId=UniProtKB:Q9Y6P5)
12. [PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
13. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
14. [p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6P5&geneProductId=UniProtKB:Q9Y6P5)
15. [p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6P5)
16. Ensembl Release 99