Serum response factor
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Transcription factor, MADS-box superfamily
additional property: PropertyValue
  property ID: P361
  value: Transcription factor, MADS-box, protein family
additional property: PropertyValue
  property ID: P361
  value: MADS SRF-like, protein family
additional property: PropertyValue
  property ID: P527
  value: Transcription factor, MADS-box
additional property: PropertyValue
  property ID: P527
  value: MADS SRF-like
additional property: PropertyValue
  property ID: P637
  value: NP_065239
additional property: PropertyValue
  property ID: P637
  value: XP_006524020
additional property: PropertyValue
  property ID: P637
  value: XP_011244638
additional property: PropertyValue
  property ID: P680
  value: protein dimerization activity
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription factor activity
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription activator activity, RNA polymerase II-specific
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: dorsal aorta morphogenesis
additional property: PropertyValue
  property ID: P682
  value: bronchus cartilage development
additional property: PropertyValue
  property ID: P682
  value: muscle cell cellular homeostasis
additional property: PropertyValue
  property ID: P702
  value: Srf
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000015749
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000156719
confidence:
  popularity graph score:
    score: 0.009
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 64
      unique citations norm: 0.025
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 64
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9JM73
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797975
    source count: 1
    confidence: 0.2
    value label: Transcription factor, MADS-box superfamily
  P361:
    value: Q83164704
    source count: 1
    confidence: 0.2
    value label: Transcription factor, MADS-box, protein family
  P361:
    value: Q83166958
    source count: 1
    confidence: 0.2
    value label: MADS SRF-like, protein family
  P527:
    value: Q24784652
    source count: 1
    confidence: 0.2
    value label: Transcription factor, MADS-box
  P527:
    value: Q27185371
    source count: 1
    confidence: 0.2
    value label: MADS SRF-like
  P637:
    value: NP_065239
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006524020
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011244638
    source count: 1
    confidence: 0.2
  P680:
    value: Q14861864
    source count: 1
    confidence: 0.2
    value label: protein dimerization activity
  P680:
    value: Q14817979
    source count: 7
    confidence: 1.0
    value label: DNA-binding transcription factor activity
  P680:
    value: Q14817973
    source count: 9
    confidence: 1.0
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P680:
    value: Q54809672
    source count: 2
    confidence: 0.4
    value label: RNA polymerase II general transcription initiation factor activity
  P680:
    value: Q21108531
    source count: 1
    confidence: 0.2
    value label: primary miRNA binding
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q40260
    source count: 6
    confidence: 1.0
    value label: nucleus
  P681:
    value: Q40260
    source count: 7
    confidence: 1.0
    value label: nucleus
  P682:
    value: Q21115825
    source count: 1
    confidence: 0.2
    value label: dorsal aorta morphogenesis
  P682:
    value: Q21127256
    source count: 1
    confidence: 0.2
    value label: bronchus cartilage development
  P682:
    value: Q14864281
    source count: 1
    confidence: 0.2
    value label: muscle cell cellular homeostasis
  P682:
    value: Q21127258
    source count: 1
    confidence: 0.2
    value label: lung smooth muscle development
  P682:
    value: Q21143729
    source count: 1
    confidence: 0.2
    value label: regulation of water loss via skin

value: Q18254335
source count: 1
confidence: 0.2
value label: Srf

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000015749
source count: 1
confidence: 0.2

value: ENSMUSP00000156719
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
stated in qid: Q39526299
retrieved: 2019-02-14

source: Actin dynamics control SRF activity by regulation of its coactivator MAL
stated in qid: Q28646140
retrieved: 2019-02-14

source: Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements
stated in qid: Q28506308
retrieved: 2019-02-14

source: Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
stated in qid: Q28585951
retrieved: 2019-02-14

source: Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
stated in qid: Q28506616
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-10-11

source: Protein Tyrosine Phosphatase-Like A Regulates Myoblast Proliferation and Differentiation through MyoG and the Cell Cycling Signaling Pathway
stated in qid: Q28505564
retrieved: 2018-10-11

source: SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
stated in qid: Q24318909
retrieved: 2018-10-11

source: Protein Tyrosine Phosphatase-Like A Regulates Myoblast Proliferation and Differentiation through MyoG and the Cell Cycling Signaling Pathway
stated in qid: Q28505564
retrieved: 2019-02-14

source: Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
stated in qid: Q28587239
retrieved: 2019-02-14

source: SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
stated in qid: Q24318909
retrieved: 2019-02-14

source: Regulation of cardiac microRNAs by serum response factor
stated in qid: Q28586225
retrieved: 2019-02-14

source: Promoter function and structure of the growth factor-inducible immediate early gene cyr61
stated in qid: Q24631079
retrieved: 2019-02-14

source: The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs
stated in qid: Q28512635
retrieved: 2019-02-14

source: SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
stated in qid: Q24313465
retrieved: 2019-02-14

source: Potentiation of serum response factor activity by a family of myocardin-related transcription factors
stated in qid: Q24313025
retrieved: 2019-02-14

source: Identification of Barx2b, a serum response factor-associated homeodomain protein
stated in qid: Q28586204
retrieved: 2019-02-14

source: Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
stated in qid: Q28505500
retrieved: 2019-02-14

source: The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression
stated in qid: Q28507680
retrieved: 2019-02-14

source: UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program
stated in qid: Q28591296
retrieved: 2019-02-14

source: UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
stated in qid: Q28484095
retrieved: 2019-02-14

source: DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation
stated in qid: Q28505964
retrieved: 2019-02-14

source: Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding
stated in qid: Q28581191
retrieved: 2019-02-14

source: Bioinformatics and cellular signaling
stated in qid: Q28506971
retrieved: 2019-02-14

source: The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling
stated in qid: Q28589959
retrieved: 2019-02-14

source: The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors
stated in qid: Q28583372
retrieved: 2019-02-14

source: Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription
stated in qid: Q28589105
retrieved: 2019-02-14

source: Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
stated in qid: Q28587239
retrieved: 2018-10-11

source: The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs
stated in qid: Q28512635
retrieved: 2018-10-11

wikidata id: Q21990643
domain: protein
level: standard
html url: https://4ort.xyz/entity/serum-response-factor-q21990643
markdown url: https://4ort.xyz/entity/serum-response-factor-q21990643.md
facts url summary: https://4ort.xyz/entity/serum-response-factor-q21990643/facts.json
facts url standard: https://4ort.xyz/entity/serum-response-factor-q21990643/facts.json
facts url full: https://4ort.xyz/entity/serum-response-factor-q21990643/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T17:44:25.951541Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:59.184953+00:00Z