# Serpin family E member 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q410485](https://www.wikidata.org/wiki/Q410485)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1)  
**Source**: https://4ort.xyz/entity/serpin-family-e-member-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05121)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
6. [Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
7. [Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
8. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
9. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
10. [Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
11. [PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
12. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
13. [Binding of PAI-1 to endothelial cells stimulated by thymosin beta4 and modulation of their fibrinolytic potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
15. [Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
16. [Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
18. [Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
20. [Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
21. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
22. [Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
23. [Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
24. [Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121)
25. [Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
26. [Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
27. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
28. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
29. [Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
30. [Anticoagulant and antithrombotic properties of platelet protease nexin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
31. [The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
32. [Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
33. [Autocrine regulation of human preadipocyte migration by plasminogen activator inhibitor-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
34. [Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
35. [Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
36. [Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
37. [Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121)
38. Ensembl Release 99
39. Identifiers.org
40. UMLS 2023
41. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)