# Serpin family E member 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561352](https://www.wikidata.org/wiki/Q28561352)  
**Source**: https://4ort.xyz/entity/serpin-family-e-member-1-q28561352


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20961)
3. Q20641742
4. [Characterization of recombinant rat plasminogen activator inhibitor-1 and development of immunological tools for its quantitation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
7. [Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
8. [Plasminogen enhances the secretion of plasminogen activator inhibitor-1 from cultured rat astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
9. [Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
10. [Effects of Kaixinjieyu, a Chinese herbal medicine preparation, on neurovascular unit dysfunction in rats with vascular depression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
11. [The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
12. [Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
13. [Studies on the role of plasminogen activators and plasminogen activator inhibitor type-1 in rat corpus luteum of pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
14. [siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
15. [Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
16. [Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
17. [Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
18. [Monoclonal antibody-based immunoassays for the specific quantitation of rat PAI-1 antigen and activity in biological samples](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
19. [Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
20. [Effects of glucose and plasminogen activator inhibitor-1 on collagen metabolism in the peritoneum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
21. [Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
22. [Regulation of proteolytic enzymes and inhibitors in two smooth muscle cell phenotypes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
23. [The induction of the immediate-early-genes Egr-1, PAI-1 and PRL-1 during liver regeneration in surgical models is related to increased portal flow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
24. [The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
25. [CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
26. [Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
27. [Transcriptional regulation of plasminogen activator inhibitor-1 by transforming growth factor-beta, activin A and microphthalmia-associated transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
28. [Presence of urokinase plasminogen activator and plasminogen activator inhibitor-1 messenger ribonucleic acids in rat endometrium during decidualization in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
29. [Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
30. [PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
31. [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
32. [Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
33. [The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
34. [Potentiating effect of endothelial cells on astrocytic plasminogen activator inhibitor type-1 gene expression in an in vitro model of the blood-brain barrier](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
35. [Plasminogen activator inhibitor type 1 up-regulation is associated with skeletal muscle atrophy and associated fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
36. [Cyclic stretch magnitude and duration affect rat alveolar epithelial gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
37. [P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
38. [Cyclic nucleotide regulation of type-1 plasminogen activator-inhibitor mRNA stability in rat hepatoma cells. Identification of cis-acting sequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
39. [Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
40. [Glibenclamide Induces Collagen IV Catabolism in High Glucose-Stimulated Mesangial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
41. [Interleukin-I-mediated regulation of plasminogen activation in pregnant mare serum gonadotropin-primed rat granulosa cells is independent of prostaglandin production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
42. [Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
43. [Plasminogen Activator Inhibitor-1 Is Expressed in Cultured Rat Sertoli Cells1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
44. [In vivo stimulation of vascular plasminogen activator inhibitor-1 production by very low-density lipoprotein involves transcription factor binding to a VLDL-responsive element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
45. [Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
46. [Regulation of Plasminogen Activator Inhibitor‐1 mRNA Accumulation by Basic Fibroblast Growth Factor and Transforming Growth Factor‐β1 in Cultured Rat Astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
47. [MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
48. [Modulation of retinal capillary endothelial cells by Müller glial cell-derived factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
49. [Aldosterone and TGF-β₁ synergistically increase PAI-1 expression in hepatic stellate cells of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)
50. [Salvia miltiorrhiza depresses plasminogen activator inhibitor-1 production through inhibition of angiotensin II.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20961)