# Serpin family A member 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q292982](https://www.wikidata.org/wiki/Q292982)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Alpha-1_antitrypsin)  
**Source**: https://4ort.xyz/entity/serpin-family-a-member-1


## References

1. Alpha-1-proteinase inhibitor. DrugBank. 2015
2. UniProt
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01009)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
7. [Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
8. [Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
9. [Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
10. [SERPINA2 is a novel gene with a divergent function from SERPINA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
11. [Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
12. [Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
13. [Alpha 1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
14. [Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
15. [Streptomyces erythraeustrypsin inactivates α1-antitrypsin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
16. [Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
17. [Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
18. [Structure of a serpin-protease complex shows inhibition by deformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
19. [Structural dynamics associated with intermediate formation in an archetypal conformational disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
20. [Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
21. [Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
22. [Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
24. [Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
25. [Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
27. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
28. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
29. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
30. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
31. [Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
32. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
33. [Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
34. [Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
35. [Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009)
36. [Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
37. [Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
38. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
39. [Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
40. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
41. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
42. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
43. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
44. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009)
45. Ensembl Release 99
46. Trypsin inhibitor, α1-. ECHA Substance Infocard database
47. NDF-RT
48. Identifiers.org
49. UMLS 2023
50. [Source](http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002739/human_med_001904.jsp)