Serine/threonine/tyrosine protein kinase RAD53 YPL153C
type: Thing
description: fungal protein found in Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P22216
additional property: PropertyValue
  property ID: P361
  value: serine/threonine-protein kinase Rad53
additional property: PropertyValue
  property ID: P361
  value: SMAD/FHA domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P527
  value: forkhead-associated (FHA) domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase domain
additional property: PropertyValue
  property ID: P527
  value: serine/threonine-protein kinase, active site
additional property: PropertyValue
  property ID: P637
  value: NP_015172
additional property: PropertyValue
  property ID: P680
  value: ATP binding
additional property: PropertyValue
  property ID: P680
  value: kinase activity
additional property: PropertyValue
  property ID: P680
  value: protein serine/threonine/tyrosine kinase activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: DNA repair
additional property: PropertyValue
  property ID: P682
  value: DNA damage checkpoint signaling
additional property: PropertyValue
  property ID: P682
  value: protein localization
additional property: PropertyValue
  property ID: P702
  value: RAD53
additional property: PropertyValue
  property ID: P703
  value: Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P705
  value: YPL153C
additional property: PropertyValue
  property ID: P3406
  value: S000006074
confidence:
  popularity graph score:
    score: 0.005
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 37
      unique citations norm: 0.015
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 37
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P22216
    source count: 1
    confidence: 0.2
  P361:
    value: Q24781613
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase Rad53
  P361:
    value: Q24725444
    source count: 1
    confidence: 0.2
    value label: SMAD/FHA domain superfamily
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q83134212
    source count: 1
    confidence: 0.2
    value label: Forkhead-associated (FHA) domain, protein family
  P361:
    value: Q83138186
    source count: 1
    confidence: 0.2
    value label: Protein kinase domain, protein family
  P527:
    value: Q24723048
    source count: 1
    confidence: 0.2
    value label: forkhead-associated (FHA) domain
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24787419
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase, active site
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P637:
    value: NP_015172
    source count: 1
    confidence: 0.2
  P680:
    value: Q14817981
    source count: 2
    confidence: 0.4
    value label: ATP binding
  P680:
    value: Q14863082
    source count: 1
    confidence: 0.2
    value label: kinase activity
  P680:
    value: Q14331146
    source count: 4
    confidence: 0.8
    value label: protein serine/threonine/tyrosine kinase activity
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14863338
    source count: 1
    confidence: 0.2
    value label: protein tyrosine kinase activity
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol
  P681:
    value: Q40260
    source count: 5
    confidence: 1.0
    value label: nucleus
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P682:
    value: Q210538
    source count: 2
    confidence: 0.4
    value label: DNA repair

value: Q14872809
source count: 2
confidence: 0.4
value label: DNA damage checkpoint signaling

value: Q14599379
source count: 1
confidence: 0.2
value label: protein localization

value: Q188941
source count: 1
confidence: 0.2
value label: cell cycle

value: Q14874965
source count: 2
confidence: 0.4
value label: DNA replication initiation

value: Q27542342
source count: 1
confidence: 0.2
value label: RAD53

value: Q27510868
source count: 1
confidence: 0.2
value label: Saccharomyces cerevisiae S288c

value: YPL153C
source count: 1
confidence: 0.2

value: S000006074
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1
stated in qid: Q58095165
retrieved: 2019-02-14

source: SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.
stated in qid: Q27935086
retrieved: 2019-02-14

source: Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae
stated in qid: Q27932610
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.
stated in qid: Q27930637
retrieved: 2019-02-14

source: CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation
stated in qid: Q33528933
retrieved: 2019-02-14

source: The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.
stated in qid: Q35634055
retrieved: 2019-02-14

source: Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
stated in qid: Q27861116
retrieved: 2019-02-14

source: A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity
stated in qid: Q24313389
retrieved: 2019-02-14

source: Defining the budding yeast chromatin‐associated interactome
stated in qid: Q27935392
retrieved: 2019-02-14

source: Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
stated in qid: Q41792126
retrieved: 2019-02-14

source: Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.
stated in qid: Q27933709
retrieved: 2019-02-14

source: Proteome survey reveals modularity of the yeast cell machinery
stated in qid: Q27929510
retrieved: 2019-02-14

source: A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
stated in qid: Q27860755
retrieved: 2019-02-14

source: Functional organization of the yeast proteome by systematic analysis of protein complexes
stated in qid: Q24292209
retrieved: 2019-02-14

source: An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks
stated in qid: Q27933571
retrieved: 2019-02-14

source: Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.
stated in qid: Q27934738
retrieved: 2019-02-14

source: DNA damage signalling targets the kinetochore to promote chromatin mobility
stated in qid: Q39177326
retrieved: 2019-02-14

source: Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint
stated in qid: Q27937738
retrieved: 2019-02-14

source: Damage-induced phosphorylation of Sld3 is important to block late origin firing
stated in qid: Q36085679
retrieved: 2019-02-14

source: Global analysis of protein phosphorylation in yeast
stated in qid: Q29615057
retrieved: 2019-02-14

source: SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.
stated in qid: Q27935086
retrieved: 2018-03-27

source: The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
stated in qid: Q27934923
retrieved: 2018-03-27

source: The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
stated in qid: Q27934923
retrieved: 2019-02-14

source: Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
stated in qid: Q27935229
retrieved: 2019-02-14

source: Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint
stated in qid: Q27929970
retrieved: 2019-02-14

source: Inhibition of the mitotic exit network in response to damaged telomeres.
stated in qid: Q27930771
retrieved: 2019-02-14

source: Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
stated in qid: Q27938580
retrieved: 2019-02-14

wikidata id: Q27549441
domain: protein
level: standard
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markdown url: https://4ort.xyz/entity/serine-threonine-tyrosine-protein-kinase-rad53-ypl153c.md
facts url summary: https://4ort.xyz/entity/serine-threonine-tyrosine-protein-kinase-rad53-ypl153c/facts.json
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facts url full: https://4ort.xyz/entity/serine-threonine-tyrosine-protein-kinase-rad53-ypl153c/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-09T17:47:07.346615Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:26:33.230374+00:00Z