# Serine/threonine/tyrosine protein kinase RAD53 YPL153C

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27549441](https://www.wikidata.org/wiki/Q27549441)  
**Source**: https://4ort.xyz/entity/serine-threonine-tyrosine-protein-kinase-rad53-ypl153c


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22216)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
5. [The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
6. [SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
7. [Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
10. [Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
11. [CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
12. [The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
13. [Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
14. [A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
15. [Defining the budding yeast chromatin‐associated interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
16. [Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
17. [Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
18. [Proteome survey reveals modularity of the yeast cell machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
19. [A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
20. [Functional organization of the yeast proteome by systematic analysis of protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
21. [An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
22. [Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
23. [DNA damage signalling targets the kinetochore to promote chromatin mobility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
24. [Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
25. [Damage-induced phosphorylation of Sld3 is important to block late origin firing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
26. [Global analysis of protein phosphorylation in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
27. [SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216)
28. [The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216)
29. [The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
30. [Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
31. [Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
32. [Inhibition of the mitotic exit network in response to damaged telomeres.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
33. [Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
34. [Checkpoint deficient rad53-11 yeast cannot accumulate dNTPs in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
35. [Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216)
36. [Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216)
37. ensembl Release 106