# Serine/threonine kinase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116513](https://www.wikidata.org/wiki/Q21116513)  
**Source**: https://4ort.xyz/entity/serine-threonine-kinase-4-q21116513


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13043)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
6. [Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
7. [The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
8. [Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
9. [A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
10. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
12. [MST1 Is a Multifunctional Caspase-Independent Inhibitor of Androgenic Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
13. [MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
14. [A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
15. [RASSF2 associates with and stabilizes the proapoptotic kinase MST2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
16. [Cloning and characterization of a member of the MST subfamily of Ste20-like kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
17. [Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
18. [MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
19. [Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
20. [Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
21. [MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
22. [The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
23. [Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
24. [Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13043&geneProductId=UniProtKB:Q13043)
25. [MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
26. [The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
27. [Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
28. [The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
29. [DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
30. [Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
31. [MST1 Is a Multifunctional Caspase-Independent Inhibitor of Androgenic Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
32. [RASSF2 associates with and stabilizes the proapoptotic kinase MST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
33. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
34. [Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
35. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
36. [The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
37. [Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
38. [MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
39. [Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
40. [Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
41. [Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
42. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
43. [Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
44. [Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
45. [Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
46. [Cloning and characterization of a member of the MST subfamily of Ste20-like kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
47. [MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
48. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
49. [The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)
50. [MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13043)