# Serine/threonine kinase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173215](https://www.wikidata.org/wiki/Q21173215)  
**Source**: https://4ort.xyz/entity/serine-threonine-kinase-3-q21173215


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13188)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
6. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
8. [MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
9. [Cloning and characterization of a member of the MST subfamily of Ste20-like kinases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
10. [Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
11. [RASSF2 associates with and stabilizes the proapoptotic kinase MST2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
12. [MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
13. [The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
14. [Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
15. [Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
16. [Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
17. [Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
18. [The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
19. [DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
20. [Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
21. [Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
22. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
23. [Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
24. [Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
25. [Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
26. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
27. [The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
28. [Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
29. [The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
30. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
31. [Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
32. [Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
33. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
34. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
35. [Cloning and characterization of a member of the MST subfamily of Ste20-like kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
36. [Detection of a novel quiescence-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
37. [Newly identified stress-responsive protein kinases, Krs-1 and Krs-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
38. [MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
39. [RASSF2 associates with and stabilizes the proapoptotic kinase MST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
41. [MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
42. [The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
43. [Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
44. [Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
45. [Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
46. [Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
47. [The Hippo pathway regulates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13188&geneProductId=UniProtKB:Q13188)
48. [Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13188)
49. Ensembl Release 99
50. UMLS 2023