# Serine/threonine kinase 11

> mammalian protein found in Mus musculus

**Wikidata**: [Q21991188](https://www.wikidata.org/wiki/Q21991188)  
**Source**: https://4ort.xyz/entity/serine-threonine-kinase-11


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
4. [LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
5. [A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
6. [LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
7. [The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
8. [The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
9. [Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
10. [LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
12. [Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
13. [LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
14. [The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
15. [Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
16. [Characterization of an alternative splice variant of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
17. [Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
18. [Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
19. [Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
20. [The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
21. [Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
22. [Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
23. [Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
24. [Lkb1 deficiency causes prostate neoplasia in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
25. [LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
26. [LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
27. [Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
28. [Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
29. [A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
30. [The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTK7&geneProductId=UniProtKB:Q9WTK7)
31. [Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
32. [Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
33. [LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
34. [Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
35. [Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTK7)
36. ensembl Release 106