# Serine/threonine kinase 11

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109306](https://www.wikidata.org/wiki/Q21109306)  
**Source**: https://4ort.xyz/entity/serine-threonine-kinase-11-q21109306


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
4. [The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
5. [Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
6. [A serine/threonine kinase gene defective in Peutz-Jeghers syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
7. [Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
8. [A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
9. [Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
10. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
11. [An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
12. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
13. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
14. [The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
15. [6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
16. [Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
17. [A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
18. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
19. [14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
20. [ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
21. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
22. [Characterization of an alternative splice variant of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
23. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15831&geneProductId=UniProtKB:Q15831)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15831&geneProductId=UniProtKB:Q15831)
25. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
26. [LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
27. [Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
28. [SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
29. [Characterization of an alternative splice variant of LKB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15831&geneProductId=UniProtKB:Q15831)
30. [Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
31. [Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15831)
32. Ensembl Release 99
33. UMLS 2023