Serine peptidase inhibitor Kazal type 5
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Kazal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Kazal domain, protein family
additional property: PropertyValue
  property ID: P486
  value: D000074163
additional property: PropertyValue
  property ID: P527
  value: Kazal domain
additional property: PropertyValue
  property ID: P637
  value: NP_001121170
additional property: PropertyValue
  property ID: P637
  value: NP_001121171
additional property: PropertyValue
  property ID: P637
  value: NP_006837
additional property: PropertyValue
  property ID: P638
  value: 1H0Z
additional property: PropertyValue
  property ID: P638
  value: 1HDL
additional property: PropertyValue
  property ID: P638
  value: 1UUC
additional property: PropertyValue
  property ID: P672
  value: D12.644.822.750.250
additional property: PropertyValue
  property ID: P672
  value: D12.776.815.688.250
additional property: PropertyValue
  property ID: P680
  value: peptidase inhibitor activity
additional property: PropertyValue
  property ID: P680
  value: serine-type endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum membrane
additional property: PropertyValue
  property ID: P682
  value: epidermal cell differentiation
additional property: PropertyValue
  property ID: P682
  value: negative regulation of proteolysis
additional property: PropertyValue
  property ID: P682
  value: negative regulation of serine-type peptidase activity
additional property: PropertyValue
  property ID: P702
  value: SPINK5
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000256084
additional property: PropertyValue
  property ID: P705
  value: ENSP00000352936
additional property: PropertyValue
  property ID: P705
  value: ENSP00000381472
additional property: PropertyValue
  property ID: P2892
  value: C4505200
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 10
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 10
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9NQ38
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797195
    source count: 1
    confidence: 0.2
    value label: Kazal domain superfamily
  P361:
    value: Q83133027
    source count: 1
    confidence: 0.2
    value label: Kazal domain, protein family
  P486:
    value: D000074163
    source count: 0
    confidence: 0.0
  P527:
    value: Q24721497
    source count: 1
    confidence: 0.2
    value label: Kazal domain
  P637:
    value: NP_001121170
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001121171
    source count: 1
    confidence: 0.2
  P637:
    value: NP_006837
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011535853
    source count: 1
    confidence: 0.2
  P638:
    value: 1H0Z
    source count: 1
    confidence: 0.2
  P638:
    value: 1HDL
    source count: 1
    confidence: 0.2
  P638:
    value: 1UUC
    source count: 1
    confidence: 0.2
  P638:
    value: 1UVF
    source count: 1
    confidence: 0.2
  P638:
    value: 1UVG
    source count: 1
    confidence: 0.2
  P672:
    value: D12.644.822.750.250
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.815.688.250
    source count: 0
    confidence: 0.0
  P680:
    value: Q14861063
    source count: 2
    confidence: 0.4
    value label: peptidase inhibitor activity
  P680:
    value: Q14859581
    source count: 3
    confidence: 0.6
    value label: serine-type endopeptidase inhibitor activity
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol
  P681:
    value: Q14329032
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum membrane
  P681:
    value: Q5058180
    source count: 1
    confidence: 0.2
    value label: cell cortex

value: Q79927
source count: 1
confidence: 0.2
value label: endoplasmic reticulum

value: Q14886408
source count: 1
confidence: 0.2
value label: epidermal cell differentiation

value: Q14758948
source count: 1
confidence: 0.2
value label: negative regulation of proteolysis

value: Q21114781
source count: 1
confidence: 0.2
value label: negative regulation of serine-type peptidase activity

value: Q14861064
source count: 1
confidence: 0.2
value label: negative regulation of peptidase activity

value: Q14863097
source count: 1
confidence: 0.2
value label: epithelial cell differentiation

value: Q18036020
source count: 1
confidence: 0.2
value label: SPINK5

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000256084
source count: 1
confidence: 0.2

value: ENSP00000352936
source count: 1
confidence: 0.2

value: ENSP00000381472
source count: 1
confidence: 0.2

value: ENSP00000421519
source count: 1
confidence: 0.2

value: ENSP00000427943
source count: 1
confidence: 0.2

value: C4505200
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution
stated in qid: Q24293118
retrieved: 2019-04-08

source: LEKTI, a novel 15-domain type of human serine proteinase inhibitor
stated in qid: Q22010419
retrieved: 2019-04-08

source: LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome
stated in qid: Q24314860
retrieved: 2019-04-08

source: LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum
stated in qid: Q24292945
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-25

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21114782
domain: protein
level: standard
html url: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-5-q21114782
markdown url: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-5-q21114782.md
facts url summary: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-5-q21114782/facts.json
facts url standard: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-5-q21114782/facts.json
facts url full: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-5-q21114782/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T10:22:34.186599Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:06.018882+00:00Z