Serine peptidase inhibitor, Kazal type 1
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P09655
additional property: PropertyValue
  property ID: P361
  value: Kazal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Kazal domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Kazal domain
additional property: PropertyValue
  property ID: P637
  value: NP_036806
additional property: PropertyValue
  property ID: P680
  value: serine-type endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P680
  value: peptidase inhibitor activity
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cytosolic calcium ion concentration
additional property: PropertyValue
  property ID: P682
  value: negative regulation of peptidase activity
additional property: PropertyValue
  property ID: P682
  value: response to nutrient levels
additional property: PropertyValue
  property ID: P702
  value: Spink1
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000018110
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P09655
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797195
    source count: 1
    confidence: 0.2
    value label: Kazal domain superfamily
  P361:
    value: Q83133027
    source count: 1
    confidence: 0.2
    value label: Kazal domain, protein family
  P527:
    value: Q24721497
    source count: 1
    confidence: 0.2
    value label: Kazal domain
  P637:
    value: NP_036806
    source count: 1
    confidence: 0.2
  P680:
    value: Q14859581
    source count: 2
    confidence: 0.4
    value label: serine-type endopeptidase inhibitor activity
  P680:
    value: Q14861063
    source count: 1
    confidence: 0.2
    value label: peptidase inhibitor activity
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region
  P681:
    value: Q1385443
    source count: 1
    confidence: 0.2
    value label: extracellular space
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P682:
    value: Q14820654
    source count: 1
    confidence: 0.2
    value label: positive regulation of cytosolic calcium ion concentration
  P682:
    value: Q14861064
    source count: 1
    confidence: 0.2
    value label: negative regulation of peptidase activity
  P682:
    value: Q14864807
    source count: 1
    confidence: 0.2
    value label: response to nutrient levels
  P682:
    value: Q14819884
    source count: 1
    confidence: 0.2
    value label: response to ethanol
  P682:
    value: Q14820076
    source count: 1
    confidence: 0.2
    value label: positive regulation of epithelial cell proliferation
  P702:
    value: Q24383188
    source count: 1
    confidence: 0.2
    value label: Spink1
  P703:
    value: Q184224
    source count: 1
    confidence: 0.2
    value label: brown rat
  P705:
    value: ENSRNOP00000018110
    source count: 1
    confidence: 0.2
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-02-14
citations:
  source: The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice
  stated in qid: Q28582773
  retrieved: 2019-02-14
citations:
  source: Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant
  stated in qid: Q28574221
  retrieved: 2019-02-14
citations:
  source: Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice
  stated in qid: Q28564328
  retrieved: 2019-02-14
citations:
  source: Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium
  stated in qid: Q28573605
  retrieved: 2019-02-14
citations:
  source: Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas
  stated in qid: Q28571800
  retrieved: 2019-02-14
citations:
  source: Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats
  stated in qid: Q28583555
  retrieved: 2019-02-14
citations:
  source: Monitor Peptide (Rat Pancreatic Secretory Trypsin Inhibitor) Directly Stimulates the Proliferation of the Nontransformed Intestinal Epithelial Cell Line, IEC-6
  stated in qid: Q28582863
  retrieved: 2019-02-14

source: Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J)
stated in qid: Q28573798
retrieved: 2019-02-14

source: Stimulatory effect of monitor peptide and human pancreatic secretory trypsin inhibitor on pancreatic secretion and cholecystokinin release in conscious rats
stated in qid: Q28581824
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28556747
domain: protein
level: standard
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facts url summary: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-1-q28556747/facts.json
facts url standard: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-1-q28556747/facts.json
facts url full: https://4ort.xyz/entity/serine-peptidase-inhibitor-kazal-type-1-q28556747/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T13:56:15.099958Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:13:20.947238+00:00Z