# sequestosome 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21106590](https://www.wikidata.org/wiki/Q21106590)  
**Source**: https://4ort.xyz/entity/sequestosome-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13501)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
5. [Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
6. [Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
7. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q13501)
8. [p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
9. [TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
10. [Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
11. [The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
12. [p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
13. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
14. [TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
15. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
16. [p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
17. [Disruption of FAT10-MAD2 binding inhibits tumor progression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
18. [FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
19. [Huntingtin functions as a scaffold for selective macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
20. [Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
21. [Phosphorylation of NBR1 by GSK3 modulates protein aggregation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
22. [Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
23. [Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
24. [Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
25. [p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
26. [The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
27. [The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
28. [Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
29. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
30. [Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
31. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
32. [Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
33. [NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
34. [Autophagy mediates degradation of nuclear lamina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
35. [Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
36. [Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
37. [A role for NBR1 in autophagosomal degradation of ubiquitinated substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
38. [Nix is a selective autophagy receptor for mitochondrial clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
39. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
40. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
41. [Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
42. [p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
43. [ATM functions at the peroxisome to induce pexophagy in response to ROS.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
44. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
45. [A directed protein interaction network for investigating intracellular signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
46. [Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
47. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
48. [p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
49. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)
50. [The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13501)