# Self-supervised machine learning methods for protein design improve sampling but not the identification of high-fitness variants

> Research article (Science Advances, 2025) · cited 13× · AI/ML

**Wikidata**: [openalex:W4407394592](https://www.wikidata.org/wiki/openalex:W4407394592)  
**Source**: https://4ort.xyz/entity/self-supervised-machine-learning-methods-for-protein-design-improve-sampling-but-not-the-identification-of-high-fitness-