Secreted protein acidic and cysteine rich
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P16975
additional property: PropertyValue
  property ID: P361
  value: Kazal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: EF-hand domain pair
additional property: PropertyValue
  property ID: P361
  value: SPARC
additional property: PropertyValue
  property ID: P527
  value: follistatin-like, N-terminal
additional property: PropertyValue
  property ID: P527
  value: SPARC/testican, calcium-binding domain
additional property: PropertyValue
  property ID: P527
  value: Kazal domain
additional property: PropertyValue
  property ID: P637
  value: NP_036788
additional property: PropertyValue
  property ID: P637
  value: XP_008765885
additional property: PropertyValue
  property ID: P680
  value: calcium ion binding
additional property: PropertyValue
  property ID: P680
  value: collagen binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: basement membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P682
  value: ossification
additional property: PropertyValue
  property ID: P682
  value: negative regulation of endothelial cell proliferation
additional property: PropertyValue
  property ID: P682
  value: development of the heart
additional property: PropertyValue
  property ID: P702
  value: Sparc
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000017486
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 24
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 24
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P16975
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797195
    source count: 1
    confidence: 0.2
    value label: Kazal domain superfamily
  P361:
    value: Q24742069
    source count: 1
    confidence: 0.2
    value label: EF-hand domain pair
  P361:
    value: Q54460122
    source count: 1
    confidence: 0.2
    value label: SPARC
  P361:
    value: Q83145976
    source count: 1
    confidence: 0.2
    value label: Follistatin/Osteonectin EGF domain, protein family
  P361:
    value: Q83147618
    source count: 1
    confidence: 0.2
    value label: Follistatin-like, N-terminal domain, protein family
  P527:
    value: Q24780686
    source count: 1
    confidence: 0.2
    value label: follistatin-like, N-terminal
  P527:
    value: Q24740008
    source count: 1
    confidence: 0.2
    value label: SPARC/testican, calcium-binding domain
  P527:
    value: Q24721497
    source count: 1
    confidence: 0.2
    value label: Kazal domain
  P527:
    value: Q24781607
    source count: 1
    confidence: 0.2
    value label: osteonectin-like, conserved site
  P527:
    value: Q24738895
    source count: 1
    confidence: 0.2
    value label: EF-hand 1, calcium-binding site
  P637:
    value: NP_036788
    source count: 1
    confidence: 0.2
  P637:
    value: XP_008765885
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633862
    source count: 4
    confidence: 0.8
    value label: calcium ion binding
  P680:
    value: Q14819451
    source count: 3
    confidence: 0.6
    value label: collagen binding
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q14864088
    source count: 2
    confidence: 0.4
    value label: extracellular matrix binding
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region
  P681:
    value: Q32846
    source count: 1
    confidence: 0.2
    value label: basement membrane
  P681:
    value: Q1385443
    source count: 5
    confidence: 1.0
    value label: extracellular space
  P681:
    value: Q40260
    source count: 1
    confidence: 0.2
    value label: nucleus

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q1121544
source count: 1
confidence: 0.2
value label: ossification

value: Q14864109
source count: 1
confidence: 0.2
value label: negative regulation of endothelial cell proliferation

value: Q471817
source count: 1
confidence: 0.2
value label: development of the heart

value: Q14864095
source count: 1
confidence: 0.2
value label: response to gravity

value: Q14859852
source count: 1
confidence: 0.2
value label: response to lead ion

value: Q24405914
source count: 1
confidence: 0.2
value label: Sparc

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000017486
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Purification of a calcium binding protein (rat SPARC) from primary Sertoli cell-enriched culture medium
stated in qid: Q28570928
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins
stated in qid: Q28570054
retrieved: 2019-02-14

source: Secreted Protein, Acidic and Rich in Cysteine (SPARC) and Thrombospondin in the Developing Follicle and Corpus Luteum of the Rat
stated in qid: Q28571082
retrieved: 2019-02-14

source: Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum.
stated in qid: Q39751809
retrieved: 2019-02-14

source: Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
stated in qid: Q35164836
retrieved: 2019-02-14

source: Gene expression and immunohistochemical localization of osteonectin in association with early bone formation in the developing mandible
stated in qid: Q28578878
retrieved: 2019-02-14

source: Coordinate gene expression during neonatal rat heart development. A possible role for the myocyte in extracellular matrix biogenesis and capillary angiogenesis
stated in qid: Q28579951
retrieved: 2019-02-14

source: Microgravity signal ensnarls cell adhesion, cytoskeleton, and matrix proteins of rat osteoblasts: osteopontin, CD44, osteonectin, and alpha-tubulin
stated in qid: Q28565325
retrieved: 2019-02-14

source: Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells
stated in qid: Q28568344
retrieved: 2019-02-14

source: SPARC participates in the branching morphogenesis of developing fetal rat lung
stated in qid: Q28572554
retrieved: 2019-02-14

source: Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat
stated in qid: Q28566774
retrieved: 2019-02-14

source: Impaired Expression of Noncollagenous Bone Matrix Protein mRNAs During Fracture Healing in Ascorbic Acid–Deficient Rats
stated in qid: Q28574804
retrieved: 2019-02-14

source: Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization
stated in qid: Q28579671
retrieved: 2019-02-14

source: Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray
stated in qid: Q28571855
retrieved: 2019-02-14

source: Effects of parathyroid hormone on bone formation in a rat model for chronic alcohol abuse
stated in qid: Q28568765
retrieved: 2019-02-14

source: Regulation of selenoprotein P mRNA expression in comparison with metallothionein and osteonectin mRNAs following cadmium and dexamethasone administration
stated in qid: Q28577971
retrieved: 2019-02-14

source: Expression of mRNA encoding extracellular matrix glycoproteins SPARC and SC1 is temporally and spatially regulated in the developing cochlea of the rat inner ear
stated in qid: Q28571596
retrieved: 2019-02-14

source: Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells
stated in qid: Q28569657
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28563329
domain: protein
level: standard
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facts url full: https://4ort.xyz/entity/secreted-protein-acidic-and-cysteine-rich-q28563329/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-09T06:46:36.926543Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:13:20.947238+00:00Z