# Scribble planar cell polarity protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116596](https://www.wikidata.org/wiki/Q21116596)  
**Source**: https://4ort.xyz/entity/scribble-planar-cell-polarity-protein-q21116596


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14160)
3. Q20641742
4. [Human scribble, a novel tumor suppressor identified as a target of high‐risk HPV E6 for ubiquitin‐mediated degradation, interacts with adenomatous polyposis coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
5. [Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
6. [The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
7. [Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
8. [MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
9. [Thyrotropin receptor trafficking relies on the hScrib–βPIX–GIT1–ARF6 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
10. [hScrib interacts with ZO‐2 at the cell–cell junctions of epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
11. [Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
12. [The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
13. [Scrib regulates PAK activity during the cell migration process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
14. [Protein tyrosine kinase 7 has a conserved role in Wnt/β‐catenin canonical signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
15. [Scribble‐mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
16. [The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
17. [The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
18. [Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
19. [The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
20. [Proteome‐wide analysis of phospho‐regulated PDZ domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
21. [The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
22. [Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
23. [The multiple‐specificity landscape of modular peptide recognition domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
24. [Defining the Human Deubiquitinating Enzyme Interaction Landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
27. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
28. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
29. [Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
31. [The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
32. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
33. [MHC class II‐associated proteins in B‐cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
34. [Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
35. [Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell‐cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
36. [The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14160&geneProductId=UniProtKB:Q14160)
37. [The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14160)
38. Ensembl Release 99