# SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21105865](https://www.wikidata.org/wiki/Q21105865)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SAMHD1)  
**Source**: https://4ort.xyz/entity/sam-and-hd-domain-containing-deoxynucleoside-triphosphate-triphosphohydrolase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y3Z3)
3. Q20641742
4. [Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
6. [SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
7. [SAMHD1 acts at stalled replication forks to prevent interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
8. [The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
9. [CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
10. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
11. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
12. [Mechanism of allosteric activation of SAMHD1 by dGTP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
13. [SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
14. [Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
15. [The ribonuclease activity of SAMHD1 is required for HIV-1 restriction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
16. [HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
17. [Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
18. [HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
19. [Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
22. [The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
23. [Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
24. [Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
25. [Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y3Z3&geneProductId=UniProtKB:Q9Y3Z3)
26. [Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
27. [Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y3Z3)
28. Ensembl Release 99
29. Identifiers.org
30. UMLS 2023
31. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)