# Ryanodine receptor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3415811](https://www.wikidata.org/wiki/Q3415811)  
**Source**: https://4ort.xyz/entity/ryanodine-receptor-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92736)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
6. [Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
7. [PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
8. [Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
9. [In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
10. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
11. [FKBP binding characteristics of cardiac microsomes from diverse vertebrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
12. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
13. [Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
16. [Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
17. [Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
18. [FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
19. [Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
21. [PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
22. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
23. [In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
24. [Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
25. [Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
26. [miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
27. [New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
28. [Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
29. [miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
30. [New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
31. [Functional relevance of the stretch-dependent slow force response in failing human myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
32. [In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92736&geneProductId=UniProtKB:Q92736)
33. [Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
34. [Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
35. [Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
36. [FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
37. [Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
38. [RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92736)
39. ensembl Release 96
40. Transporter Classification database