# Ryanodine receptor 2, cardiac

> mammalian protein found in Mus musculus

**Wikidata**: [Q21498437](https://www.wikidata.org/wiki/Q21498437)  
**Source**: https://4ort.xyz/entity/ryanodine-receptor-2-cardiac


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/E9Q401)
3. Q20641742
4. [Molecular identification of the ryanodine receptor pore-forming segment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
6. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
7. [The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
8. [Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
10. [Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
11. [Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
12. [Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
13. [Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
14. [Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
15. [The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
16. [Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
17. [Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
18. [The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
19. [Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
20. [The Predicted TM10 Transmembrane Sequence of the Cardiac Ca2+ Release Channel (Ryanodine Receptor) Is Crucial for Channel Activation and Gating](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
21. [Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
22. [Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
23. [Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
25. [The Predicted TM10 Transmembrane Sequence of the Cardiac Ca2+ Release Channel (Ryanodine Receptor) Is Crucial for Channel Activation and Gating](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
26. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
27. [Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
28. [Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
29. [Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
30. [Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
31. [Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
32. [Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
33. [FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
34. [Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=E9Q401&geneProductId=UniProtKB:E9Q401)
35. [Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
36. [Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
37. [Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
38. [FKBP12.6 and cADPR regulation of Ca2+release in smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
39. [The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
40. [Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
41. [RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
42. [FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
43. [Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
44. [Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
45. [RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E9Q401)
46. ensembl Release 106