# Ryanodine receptor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21138907](https://www.wikidata.org/wiki/Q21138907)  
**Source**: https://4ort.xyz/entity/ryanodine-receptor-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21817)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
6. [A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
7. [Functional characterization of a distinct ryanodine receptor mutation in human malignant hyperthermia-susceptible muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
9. [New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
10. [Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
11. [Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
12. [Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
13. [3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
15. [New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
16. [Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
17. [Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
18. [Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
19. [3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
20. [Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
21. [Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
22. [Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
23. [FK506 binding protein associated with the calcium release channel (ryanodine receptor)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
24. [Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
25. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
26. [Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21817&geneProductId=UniProtKB:P21817)
27. [Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
28. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
29. [Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
30. [The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21817)
31. Ensembl Release 99
32. Transporter Classification database