# RUNX family transcription factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4392325](https://www.wikidata.org/wiki/Q4392325)  
**Source**: https://4ort.xyz/entity/runx-family-transcription-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q01196)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
5. [A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
6. [Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
7. [The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
8. [A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
9. [Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
10. [Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
11. [Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
12. [Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
13. [RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
14. [Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
15. [Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
16. [Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
17. [MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
18. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
19. [Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
20. [Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
21. [Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
22. [Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
23. [Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
24. [Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
25. [LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
27. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
28. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
30. [Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
31. [Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
32. [Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
33. [Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
34. [Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
35. [Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01196)
36. [RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01196&geneProductId=UniProtKB:Q01196)
37. Ensembl Release 99