# Runt related transcription factor 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q14907088](https://www.wikidata.org/wiki/Q14907088)  
**Source**: https://4ort.xyz/entity/runt-related-transcription-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q08775)
3. Q20641742
4. [SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
6. [Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
7. [Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
8. [A twist code determines the onset of osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
9. [Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
10. [Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
11. [Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
12. [The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
13. [Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
14. [A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
15. [Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
16. [Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
17. [Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
18. [Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
19. [Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
20. [Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
21. [Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
22. [p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
24. [Participation of Runx2 in mandibular condylar cartilage development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
26. [The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
27. [Participation of Runx2 in mandibular condylar cartilage development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
28. [SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
29. [Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
30. [Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
31. [Cbfbeta interacts with Runx2 and has a critical role in bone development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
32. [Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08775&geneProductId=UniProtKB:Q08775)
33. [Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
34. [The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
35. [SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
36. [Cbfbeta interacts with Runx2 and has a critical role in bone development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
37. [Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
38. [Phenotypic changes in dentition of Runx2 homozygote-null mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
39. [Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
40. [Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
41. [PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
42. [Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
43. [Maturational disturbance of chondrocytes in Cbfa1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
44. [The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
45. [Regulation of chondrocyte differentiation by Cbfa1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
46. [Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
47. [Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
48. [Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
49. [A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)
50. [Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08775)