# RPTOR independent companion of MTOR complex 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116071](https://www.wikidata.org/wiki/Q21116071)  
**Source**: https://4ort.xyz/entity/rptor-independent-companion-of-mtor-complex-2-q21116071


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q6R327)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
5. [PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
6. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
7. [Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
8. [Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
9. [Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
10. [mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
11. [mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
12. [Activation of mTORC2 by Association with the Ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
13. [Identification of Protor as a novel Rictor-binding component of mTOR complex-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
14. [SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
15. [P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
16. [HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
17. [DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
18. [Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
19. [The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
20. [Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
21. [Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
22. [Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
24. [A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327)
26. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327)
27. [Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327)
28. [PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327)
29. [Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
30. [Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327)
31. Ensembl Release 99
32. UMLS 2023