# Rous sarcoma oncogene

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984733](https://www.wikidata.org/wiki/Q21984733)  
**Source**: https://4ort.xyz/entity/rous-sarcoma-oncogene


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05480)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
5. [Identification of a ten-amino acid proline-rich SH3 binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05480&geneProductId=UniProtKB:P05480)
7. [Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
8. [Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
9. [Src kinase activity is essential for osteoclast function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
10. [Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
11. [Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
12. [The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
13. [A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
14. [Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
15. [Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
16. [Dishevelled-2 docks and activates Src in a Wnt-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
17. [CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
18. [A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
19. [Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
20. [Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
21. [Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
22. [Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
23. [Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
24. [A proteomics strategy for the enrichment of receptor-associated complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
25. [Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
26. [Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
27. [NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
28. [EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
29. [Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
30. [Src kinase activation by direct interaction with the integrin β cytoplasmic domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
31. [PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
32. [Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
33. [Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
34. [c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
35. [Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
37. [Abl Family Kinases Regulate FcγR-Mediated Phagocytosis in Murine Macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
38. [Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
39. [Gab1 is an integrator of cell death versus cell survival signals in oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
40. [EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
41. [Regulation of connexin43 protein complexes by intracellular acidification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
42. [Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
43. [A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
44. [The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
45. [Mechanical Loading in Osteocytes Induces Formation of a Src/Pyk2/MBD2 Complex That Suppresses Anabolic Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
46. [Src-dependent phosphorylation of ASAP1 regulates podosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
47. [c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
48. [Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)
49. [Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05480&geneProductId=UniProtKB:P05480)
50. [Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480)