# Roundabout 1 Dmel_CG13521

> protein found in Drosophila melanogaster

**Wikidata**: [Q29819551](https://www.wikidata.org/wiki/Q29819551)  
**Source**: https://4ort.xyz/entity/roundabout-1-dmel-cg13521


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9W213)
3. Q20641742
4. [Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
5. [Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
6. [LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
7. [A molecular mechanism for the heparan sulfate dependence of slit-robo signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
8. [Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
10. [Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
11. [Intra-axonal patterning: intrinsic compartmentalization of the axonal membrane in Drosophila neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
12. [Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
13. [Slit is the midline repellent for the robo receptor in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
14. [Cellular components and signals required for the cardiac outflow tract assembly in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
15. [Branching morphogenesis of the Drosophila tracheal system.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9W213&geneProductId=UniProtKB:Q9W213)
16. [NETRIN and SLIT guide salivary gland migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
17. [Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
18. [Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
19. [A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
20. [The axon-guidance roundabout gene alters the pace of the Drosophila circadian clock.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
21. [Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
22. [Abelson tyrosine kinase is required to transduce midline repulsive cues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
23. [beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
24. [Altered levels of Gq activity modulate axonal pathfinding in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
25. [The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
26. [Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
27. [Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
28. [Slit and Robo control cardiac cell polarity and morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
29. [Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
30. [Genetic control of dendritic morphogenesis in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
31. [Dendritic development: lessons from Drosophila and related branches.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
32. [Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
33. [Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
34. [Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
35. [New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
36. [Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
37. [Axon guidance: the cytoplasmic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
38. [Endocytosis in Drosophila: Progress, Possibilities, Prognostications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
39. [The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
40. [ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
41. [Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
42. [Integrins regulate responsiveness to slit repellent signals.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
43. [Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
44. [Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W213)
45. ensembl Release 106