# Ring finger protein 31

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115401](https://www.wikidata.org/wiki/Q21115401)  
**Source**: https://4ort.xyz/entity/ring-finger-protein-31-q21115401


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96EP0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
5. [A ubiquitin ligase complex assembles linear polyubiquitin chains](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
6. [SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
7. [SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
8. [Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
9. [Molecular Basis and Regulation of OTULIN-LUBAC Interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
10. [Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
11. [The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
12. [The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
13. [CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
14. [Linear ubiquitination prevents inflammation and regulates immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
15. [Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
16. [A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
17. [Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
18. [LUBAC regulates NF‐κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
19. [Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
20. [Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
21. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
22. [LUBAC synthesizes linear ubiquitin chains via a thioester intermediate](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
23. [Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
24. [A non‐canonical UBA–UBL interaction forms the linear‐ubiquitin‐chain assembly complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
25. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
26. [The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
27. [HOIL-1L Interacting Protein (HOIP) as an NF-κB Regulating Component of the CD40 Signaling Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
28. [High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
29. [Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
30. [Involvement of linear polyubiquitylation of NEMO in NF-κB activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
31. [Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EP0&geneProductId=UniProtKB:Q96EP0)
32. Ensembl Release 99