# Ring-box 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21117428](https://www.wikidata.org/wiki/Q21117428)  
**Source**: https://4ort.xyz/entity/ring-box-1


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL468)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P62877)
5. Q20641742
6. [ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
8. [The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
10. [ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
11. [E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
12. [SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
13. [CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
14. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
15. [NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
16. [CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
17. [Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
18. [COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
19. [CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
20. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
21. [Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
22. [Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
23. [RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
24. [Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
25. [Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
26. [TIP120A associates with cullins and modulates ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
27. [VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
28. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
29. [F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
30. [A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
31. [Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
32. [ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
33. [The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
34. [Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
35. [Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
36. [E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
37. [Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
39. [The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
40. [Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
41. [The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
42. [Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
43. [FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
44. [SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
45. [SCFFBXL15regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
46. [The novel human DNA helicase hFBH1 is an F-box protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62877)
47. [ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
48. [A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
49. [Ubiquitin-dependent regulation of COPII coat size and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)
50. [The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62877&geneProductId=UniProtKB:P62877)