# Ribosomal protein S6 kinase B1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114975](https://www.wikidata.org/wiki/Q21114975)  
**Source**: https://4ort.xyz/entity/ribosomal-protein-s6-kinase-b1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545076)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P23443)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
6. [Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
7. [S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
8. [S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
9. [Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
10. [SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
11. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
12. [PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
13. [B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
14. [Visualization of biochemical networks in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
15. [Immediate‐early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
16. [The crosstalk of mTOR/S6K1 and Hedgehog pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
17. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23443&geneProductId=UniProtKB:P23443)
20. [Regulation and localization of ribosomal protein S6 kinase 1 isoforms](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23443&geneProductId=UniProtKB:P23443)
21. [mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
22. [The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23443&geneProductId=UniProtKB:P23443)
23. [Phosphorylation and activation of p70s6k by PDK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
24. [EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
25. [Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
26. [The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23443)
27. Ensembl Release 99