# Rho/Rac guanine nucleotide exchange factor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21171608](https://www.wikidata.org/wiki/Q21171608)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ARHGEF2)  
**Source**: https://4ort.xyz/entity/rho-rac-guanine-nucleotide-exchange-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92974)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
5. [Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
6. [Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
7. [GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
8. [Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
9. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
10. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
11. [p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
12. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92974&geneProductId=UniProtKB:Q92974)
14. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92974&geneProductId=UniProtKB:Q92974)
15. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
16. [Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974)
17. Ensembl Release 99