# Rho guanine nucleotide exchange factor 7

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21101948](https://www.wikidata.org/wiki/Q21101948)  
**Source**: https://4ort.xyz/entity/rho-guanine-nucleotide-exchange-factor-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14155)
3. Q20641742
4. [Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
5. [Mammalian Scribble forms a tight complex with the betaPIX exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
6. [Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
7. [The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
8. [Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
9. [ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
10. [betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
11. [The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
12. [Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
13. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
14. [An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
15. [Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
16. [N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
18. [Nox1 activation by βPix and the role of Ser‐340 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
19. [GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
20. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
21. [Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
22. [MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
23. [Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
24. [Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
25. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
26. [Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
28. [Synapse formation is regulated by the signaling adaptor GIT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
29. [Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
30. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
31. [PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14155&geneProductId=UniProtKB:Q14155)
32. Ensembl Release 99