Rho-associated protein kinase let-502 CELE_C10H11.9
type: Thing
description: protein found in Caenorhabditis elegans
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P92199
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: PH-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Rho-associated protein kinase LET-502
additional property: PropertyValue
  property ID: P527
  value: protein kinase domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase C-like, phorbol ester/diacylglycerol-binding domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P637
  value: NP_491440
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P680
  value: protein serine/threonine kinase activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoskeleton
additional property: PropertyValue
  property ID: P682
  value: nematode larval development
additional property: PropertyValue
  property ID: P682
  value: protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: Rho protein signal transduction
additional property: PropertyValue
  property ID: P702
  value: let-502
additional property: PropertyValue
  property ID: P703
  value: Caenorhabditis elegans
additional property: PropertyValue
  property ID: P705
  value: C10H11.9
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 10
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 10
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P92199
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q24786013
    source count: 1
    confidence: 0.2
    value label: PH-like domain superfamily
  P361:
    value: Q24726525
    source count: 1
    confidence: 0.2
    value label: Rho-associated protein kinase LET-502
  P361:
    value: Q83134938
    source count: 1
    confidence: 0.2
    value label: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family
  P361:
    value: Q83137468
    source count: 1
    confidence: 0.2
    value label: AGC-kinase, C-terminal domain, protein family
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24724299
    source count: 1
    confidence: 0.2
    value label: protein kinase C-like, phorbol ester/diacylglycerol-binding domain
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24741088
    source count: 1
    confidence: 0.2
    value label: AGC-kinase, C-terminal
  P527:
    value: Q24787419
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase, active site
  P637:
    value: NP_491440
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14820641
    source count: 1
    confidence: 0.2
    value label: protein kinase activity
  P680:
    value: Q14326094
    source count: 3
    confidence: 0.6
    value label: protein serine/threonine kinase activity
  P680:
    value: Q14817981
    source count: 2
    confidence: 0.4
    value label: ATP binding
  P680:
    value: Q14863082
    source count: 1
    confidence: 0.2
    value label: kinase activity
  P681:
    value: Q40260
    source count: 1
    confidence: 0.2
    value label: nucleus
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q154626
    source count: 1
    confidence: 0.2
    value label: cytoskeleton
  P681:
    value: Q5130989
    source count: 1
    confidence: 0.2
    value label: cleavage furrow
  P681:
    value: Q14864851
    source count: 1
    confidence: 0.2
    value label: contractile fiber
  P682:
    value: Q22298503
    source count: 1
    confidence: 0.2
    value label: nematode larval development

value: Q7251493
source count: 2
confidence: 0.4
value label: protein phosphorylation

value: Q14860470
source count: 1
confidence: 0.2
value label: Rho protein signal transduction

value: Q14645705
source count: 1
confidence: 0.2
value label: multicellular organism development

value: Q14819462
source count: 1
confidence: 0.2
value label: regulation of cell shape

value: Q29660540
source count: 1
confidence: 0.2
value label: let-502

value: Q91703
source count: 1
confidence: 0.2
value label: Caenorhabditis elegans

value: C10H11.9
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape
stated in qid: Q47069251
retrieved: 2018-01-01

source: The Caenorhabditis elegans mel-11 myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway
stated in qid: Q47069027
retrieved: 2018-01-01

source: TheCaenorhabditis elegansnonmuscle myosin genesnmy-1andnmy-2function as redundant components of thelet-502/Rho-binding kinase andmel-11/myosin phosphatase pathway during embryonic morphogenesis
stated in qid: Q47069469
retrieved: 2018-01-01

source: Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx
stated in qid: Q34003205
retrieved: 2018-01-01

source: Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles
stated in qid: Q43292869
retrieved: 2018-01-01

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-12-05

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-12-14

source: ensembl Release 96
stated in qid: Q63170780

wikidata id: Q29792740
domain: protein
level: standard
html url: https://4ort.xyz/entity/rho-associated-protein-kinase-let-502-cele-c10h11-9
markdown url: https://4ort.xyz/entity/rho-associated-protein-kinase-let-502-cele-c10h11-9.md
facts url summary: https://4ort.xyz/entity/rho-associated-protein-kinase-let-502-cele-c10h11-9/facts.json
facts url standard: https://4ort.xyz/entity/rho-associated-protein-kinase-let-502-cele-c10h11-9/facts.json
facts url full: https://4ort.xyz/entity/rho-associated-protein-kinase-let-502-cele-c10h11-9/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T21:42:46.258381Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:58:52.713056+00:00Z