# Rho associated coiled-coil containing protein kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21127094](https://www.wikidata.org/wiki/Q21127094)  
**Source**: https://4ort.xyz/entity/rho-associated-coiled-coil-containing-protein-kinase-2-q21127094


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75116)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
6. [Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
7. [Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
9. [Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
10. [Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
11. [Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
12. [Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
13. [Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
14. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
15. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
16. [ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
17. [Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
18. [Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
19. [Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
20. [Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
21. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
22. [Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
23. [Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
25. [The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
26. [Rocks: multifunctional kinases in cell behaviour](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
27. [Regulation of RhoA-dependent ROCKII activation by Shp2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
28. [Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
29. [Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
30. [Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
31. [Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
32. [Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75116&geneProductId=UniProtKB:O75116)
33. [Downregulation of the Rho GTPase signaling pathway is involved in the microRNA‐138‐mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75116)
34. Ensembl Release 99