# Rho associated coiled-coil containing protein kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100658](https://www.wikidata.org/wiki/Q21100658)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ROCK1)  
**Source**: https://4ort.xyz/entity/rho-associated-coiled-coil-containing-protein-kinase-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3426621)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1667969)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545065)
6. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13464)
7. Q20641742
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
9. [Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
10. [Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
12. [Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
13. [The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
14. [Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
15. [Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
16. [Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
17. [Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13464&geneProductId=UniProtKB:Q13464)
18. [Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
19. [Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
20. [Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
21. [Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
22. [MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
23. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
24. [FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
25. [Structural insights into the interaction of ROCKI with the switch regions of RhoA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
26. [ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
27. [Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
28. [The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
29. [Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
30. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
31. [Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
33. [Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
34. [Rocks: multifunctional kinases in cell behaviour](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
35. [Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
36. [Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
37. [Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
38. [Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
39. [Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
40. [Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
41. [Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
42. [Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13464)
43. Ensembl Release 99
44. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)