# retinoid X receptor alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118710](https://www.wikidata.org/wiki/Q21118710)  
**Source**: https://4ort.xyz/entity/retinoid-x-receptor-alpha


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19793)
4. Q20641742
5. [A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
7. [Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
8. [Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
9. [Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
10. [Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
11. [Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
12. [Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19793&geneProductId=UniProtKB:P19793)
14. [An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19793&geneProductId=UniProtKB:P19793)
15. [The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
16. [Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
17. [Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
18. [The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
19. [Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
20. [MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
21. [Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
22. [Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
23. [Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
24. [Helix 11 dynamics is critical for constitutive androstane receptor activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
25. [Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
26. [Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
27. [ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
28. [Molecular determinants of the interactions between SRC‐1 and LXR/RXR heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
29. [Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
30. [Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
31. [Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
32. [NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
33. [Enhancer activation requires trans-recruitment of a mega transcription factor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
34. [A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
35. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
36. [Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
37. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
38. [Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
39. [The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
40. [Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
41. [Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
42. [9-cis retinoic acid is a high affinity ligand for the retinoid X receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19793&geneProductId=UniProtKB:P19793)
43. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
44. [9-cis retinoic acid is a high affinity ligand for the retinoid X receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
45. [RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
46. [An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
47. [The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
48. [Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
49. [Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19793)
50. Ensembl Release 99