# ret proto-oncogene

> mammalian protein found in Homo sapiens

**Wikidata**: [Q415976](https://www.wikidata.org/wiki/Q415976)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/RET_proto-oncogene)  
**Source**: https://4ort.xyz/entity/ret-proto-oncogene


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P07949)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
7. [Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
8. [GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
9. [Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
10. [GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
11. [Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
12. [Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
13. [MEN2A-RET-induced cellular transformation by activation of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
14. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
15. [The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
16. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
17. [SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
18. [Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
19. [Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
21. [GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
24. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
25. [Direct visualization of vesicle maturation and plasma membrane protein trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
26. [Direct visualization of vesicle maturation and plasma membrane protein trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
27. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
28. [Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
29. [RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
30. [RET-mediated cell adhesion and migration require multiple integrin subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
31. [Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
32. [RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
33. [The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
34. [Mutations of the RET proto-oncogene in Hirschsprung's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949)
35. [GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates](http://www.ebi.ac.uk/QuickGO/annotations?protein=P07949&geneProductId=UniProtKB:P07949)
36. Ensembl Release 99
37. Identifiers.org
38. UMLS 2023
39. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)