# Response surface methodology based on central composite design accompanied by multivariate curve resolution to model gradient hydrophilic interaction liquid chromatography: Prediction of separation for five major opium alkaloids

> Research article (Journal of Separation Science, 2017) · cited 13× · AI/ML

**Wikidata**: [openalex:W2734959100](https://www.wikidata.org/wiki/openalex:W2734959100)  
**Source**: https://4ort.xyz/entity/response-surface-methodology-based-on-central-composite-design-accompanied-by-multivariate-curve-resolution-to-model-gra