Replication factor C subunit 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P35251
additional property: PropertyValue
  property ID: P361
  value: Replication factor C subunit 1
additional property: PropertyValue
  property ID: P361
  value: DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P527
  value: AAA+ ATPase domain
additional property: PropertyValue
  property ID: P527
  value: DNA replication factor RFC1, C-terminal
additional property: PropertyValue
  property ID: P527
  value: BRCT domain
additional property: PropertyValue
  property ID: P637
  value: NP_001191676
additional property: PropertyValue
  property ID: P637
  value: NP_002904
additional property: PropertyValue
  property ID: P637
  value: XP_011512033
additional property: PropertyValue
  property ID: P638
  value: 2EBU
additional property: PropertyValue
  property ID: P638
  value: 2K6G
additional property: PropertyValue
  property ID: P638
  value: 2K7F
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: enzyme activator activity
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: extracellular exosome
additional property: PropertyValue
  property ID: P681
  value: DNA replication factor C complex
additional property: PropertyValue
  property ID: P682
  value: DNA-dependent DNA replication
additional property: PropertyValue
  property ID: P682
  value: nucleotide-excision repair, DNA gap filling
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P702
  value: RFC1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000261424
additional property: PropertyValue
  property ID: P705
  value: ENSP00000371321
additional property: PropertyValue
  property ID: P705
  value: ENSP00000422129
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P35251
    source count: 1
    confidence: 0.2
  P361:
    value: Q24780584
    source count: 1
    confidence: 0.2
    value label: Replication factor C subunit 1
  P361:
    value: Q24785952
    source count: 1
    confidence: 0.2
    value label: DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q41797533
    source count: 1
    confidence: 0.2
    value label: BRCT domain superfamily
  P361:
    value: Q83141736
    source count: 1
    confidence: 0.2
    value label: ATPase, AAA-type, core domain, protein family
  P527:
    value: Q24774001
    source count: 1
    confidence: 0.2
    value label: AAA+ ATPase domain
  P527:
    value: Q24769728
    source count: 1
    confidence: 0.2
    value label: DNA replication factor RFC1, C-terminal
  P527:
    value: Q24769383
    source count: 1
    confidence: 0.2
    value label: BRCT domain
  P527:
    value: Q24774628
    source count: 1
    confidence: 0.2
    value label: ATPase, AAA-type, core
  P637:
    value: NP_001191676
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002904
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011512033
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350424
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350425
    source count: 1
    confidence: 0.2
  P638:
    value: 2EBU
    source count: 1
    confidence: 0.2
  P638:
    value: 2K6G
    source count: 1
    confidence: 0.2
  P638:
    value: 2K7F
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding

value: Q167149
source count: 3
confidence: 0.6
value label: protein binding

value: Q14878167
source count: 1
confidence: 0.2
value label: enzyme activator activity

value: Q14817981
source count: 3
confidence: 0.6
value label: ATP binding

value: Q21115923
source count: 1
confidence: 0.2
value label: DNA clamp loader activity

value: Q14817956
source count: 2
confidence: 0.4
value label: nucleoplasm

value: Q903634
source count: 1
confidence: 0.2
value label: extracellular exosome

value: Q14902224
source count: 2
confidence: 0.4
value label: DNA replication factor C complex

value: Q40260
source count: 4
confidence: 0.8
value label: nucleus

value: Q30869
source count: 1
confidence: 0.2
value label: nucleolus

value: Q21101120
source count: 1
confidence: 0.2
value label: DNA-dependent DNA replication

value: Q14902243
source count: 1
confidence: 0.2
value label: nucleotide-excision repair, DNA gap filling

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q15315123
source count: 1
confidence: 0.2
value label: telomere maintenance via telomerase

value: Q21109271
source count: 1
confidence: 0.2
value label: error-free translesion synthesis

value: Q18031096
source count: 1
confidence: 0.2
value label: RFC1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000261424
source count: 1
confidence: 0.2

value: ENSP00000371321
source count: 1
confidence: 0.2

value: ENSP00000422129
source count: 1
confidence: 0.2

value: ENSP00000422475
source count: 1
confidence: 0.2

value: ENSP00000422740
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Direct interaction between cohesin complex and DNA replication machinery
stated in qid: Q24302104
retrieved: 2019-04-08

source: The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival
stated in qid: Q24338352
retrieved: 2019-04-08

source: Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity
stated in qid: Q24314915
retrieved: 2019-04-08

source: Replication factor C recognizes 5'-phosphate ends of telomeres
stated in qid: Q24329092
retrieved: 2019-04-08

source: cDNAs encoding the large subunit of human replication factor C
stated in qid: Q24320998
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
stated in qid: Q36525659
retrieved: 2019-04-08

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-09-26

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-09-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21127023
domain: protein
level: standard
html url: https://4ort.xyz/entity/replication-factor-c-subunit-1-q21127023
markdown url: https://4ort.xyz/entity/replication-factor-c-subunit-1-q21127023.md
facts url summary: https://4ort.xyz/entity/replication-factor-c-subunit-1-q21127023/facts.json
facts url standard: https://4ort.xyz/entity/replication-factor-c-subunit-1-q21127023/facts.json
facts url full: https://4ort.xyz/entity/replication-factor-c-subunit-1-q21127023/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-18T19:58:47.960283Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:14.966657+00:00Z