# Regulatory associated protein of MTOR complex 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115067](https://www.wikidata.org/wiki/Q21115067)  
**Source**: https://4ort.xyz/entity/regulatory-associated-protein-of-mtor-complex-1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL571209)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8N122)
4. Q20641742
5. [AMPK phosphorylation of raptor mediates a metabolic checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
6. [Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
7. [Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
8. [mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
9. [PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
10. [Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
11. [La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
12. [5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
13. [PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
14. [mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
15. [Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
16. [The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
17. [HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
18. [cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
19. [Architecture of human mTOR complex 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
20. [Huntingtin functions as a scaffold for selective macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
21. [The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
22. [GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
23. [Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
24. [Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
25. [Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
26. [Probing cellular protein complexes using single-molecule pull-down](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
27. [Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
28. [mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
29. [mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
30. [Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
31. [Rab1A is an mTORC1 activator and a colorectal oncogene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
32. [Identification of Protor as a novel Rictor-binding component of mTOR complex-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
33. [DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
34. [Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
35. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
36. [Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
37. [SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
38. [Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
39. [SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
40. [P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
41. [The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
42. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
43. [Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
44. [GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N122)
46. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
47. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
48. [Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
49. [GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)
50. [Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N122&geneProductId=UniProtKB:Q8N122)