Regulator of G-protein signaling 6
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: winged helix DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: G-protein gamma-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: RGS domain superfamily
additional property: PropertyValue
  property ID: P527
  value: RGS domain
additional property: PropertyValue
  property ID: P527
  value: DEP domain
additional property: PropertyValue
  property ID: P527
  value: G-protein gamma-like domain
additional property: PropertyValue
  property ID: P637
  value: NP_001268990
additional property: PropertyValue
  property ID: P637
  value: NP_001297407
additional property: PropertyValue
  property ID: P637
  value: NP_056627
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: GTPase activator activity
additional property: PropertyValue
  property ID: P680
  value: protein domain specific binding
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: positive regulation of GTPase activity
additional property: PropertyValue
  property ID: P682
  value: negative regulation of signal transduction
additional property: PropertyValue
  property ID: P702
  value: Rgs6
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000139735
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000143801
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000143961
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 8
      unique citations norm: 0.003
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 8
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9Z2H2
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797505
    source count: 1
    confidence: 0.2
    value label: winged helix DNA-binding domain superfamily
  P361:
    value: Q41797405
    source count: 1
    confidence: 0.2
    value label: G-protein gamma-like domain superfamily
  P361:
    value: Q41797425
    source count: 1
    confidence: 0.2
    value label: RGS domain superfamily
  P361:
    value: Q41797502
    source count: 1
    confidence: 0.2
    value label: Winged helix-like DNA-binding domain superfamily
  P361:
    value: Q24778503
    source count: 1
    confidence: 0.2
    value label: RGS, subdomain 1/3
  P527:
    value: Q24772227
    source count: 1
    confidence: 0.2
    value label: RGS domain
  P527:
    value: Q24722463
    source count: 1
    confidence: 0.2
    value label: DEP domain
  P527:
    value: Q24743749
    source count: 1
    confidence: 0.2
    value label: G-protein gamma-like domain
  P527:
    value: Q54460554
    source count: 1
    confidence: 0.2
    value label: RGS6, RGS domain
  P637:
    value: NP_001268990
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001297407
    source count: 1
    confidence: 0.2
  P637:
    value: NP_056627
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006516133
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011242435
    source count: 1
    confidence: 0.2
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P680:
    value: Q14908102
    source count: 4
    confidence: 0.8
    value label: GTPase activator activity
  P680:
    value: Q14860854
    source count: 1
    confidence: 0.2
    value label: protein domain specific binding
  P681:
    value: Q220599
    source count: 3
    confidence: 0.6
    value label: cytosol
  P681:
    value: Q29548
    source count: 2
    confidence: 0.4
    value label: plasma membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q40260
    source count: 1
    confidence: 0.2
    value label: nucleus

value: Q14864520
source count: 2
confidence: 0.4
value label: extrinsic component of membrane

value: Q14758909
source count: 2
confidence: 0.4
value label: G protein-coupled receptor signaling pathway

value: Q14906083
source count: 2
confidence: 0.4
value label: positive regulation of GTPase activity

value: Q14905137
source count: 1
confidence: 0.2
value label: negative regulation of signal transduction

value: Q14851952
source count: 1
confidence: 0.2
value label: intracellular signal transduction

value: Q14852017
source count: 1
confidence: 0.2
value label: positive regulation of neuron differentiation

value: Q18256855
source count: 1
confidence: 0.2
value label: Rgs6

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000139735
source count: 1
confidence: 0.2

value: ENSMUSP00000143801
source count: 1
confidence: 0.2

value: ENSMUSP00000143961
source count: 1
confidence: 0.2

value: ENSMUSP00000098793
source count: 1
confidence: 0.2

value: ENSMUSP00000125256
source count: 1
confidence: 0.2

source: GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
stated in qid: Q24605032
retrieved: 2019-02-14

source: A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes
stated in qid: Q28511026
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21980150
domain: protein
level: standard
html url: https://4ort.xyz/entity/regulator-of-g-protein-signaling-6-q21980150
markdown url: https://4ort.xyz/entity/regulator-of-g-protein-signaling-6-q21980150.md
facts url summary: https://4ort.xyz/entity/regulator-of-g-protein-signaling-6-q21980150/facts.json
facts url standard: https://4ort.xyz/entity/regulator-of-g-protein-signaling-6-q21980150/facts.json
facts url full: https://4ort.xyz/entity/regulator-of-g-protein-signaling-6-q21980150/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T10:22:24.622681Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:29.049494+00:00Z