# Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases

> Research article (Journal of Biological Chemistry, 2017) · cited 29× · AI/ML

**Wikidata**: [openalex:W2737788517](https://www.wikidata.org/wiki/openalex:W2737788517)  
**Source**: https://4ort.xyz/entity/reconstructed-ancestral-enzymes-reveal-that-negative-selection-drove-the-evolution-of-substrate-specificity-in-adp-depen