# receptor interacting serine/threonine kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111679](https://www.wikidata.org/wiki/Q21111679)  
**Source**: https://4ort.xyz/entity/receptor-interacting-serine-threonine-kinase-2-q21111679


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43353)
3. [Swiss-Prot](http://www.uniprot.org/uniprot/O43353.txt?version=170)
4. Q20641742
5. [TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
7. [Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
8. [Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
9. [The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
10. [Evaluation of Nod-like receptor (NLR) effector domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
11. [Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
12. [Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
13. [An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
14. [Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
15. [Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
16. [INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
17. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
18. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
19. [XIAP mediates NOD signaling via interaction with RIP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
20. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
21. [TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
22. [Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
23. [Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
24. [Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
25. [Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
26. [cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
27. [RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
28. [RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
30. [Activation of Interferon Regulatory Factor 5 by Site Specific Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
31. [OTULIN restricts Met1-linked ubiquitination to control innate immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
32. [Identification of CARDIAK, a RIP-like kinase that associates with caspase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
33. [The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
34. [RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
35. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
36. [OTULIN restricts Met1-linked ubiquitination to control innate immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
37. [Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
38. [cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
39. [CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43353&geneProductId=UniProtKB:O43353)
40. [CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
41. [Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43353)
42. Ensembl Release 99
43. UMLS 2023