# RB binding protein 8, endonuclease

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100486](https://www.wikidata.org/wiki/Q21100486)  
**Source**: https://4ort.xyz/entity/rb-binding-protein-8-endonuclease


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99708)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
5. [RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
6. [RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
7. [CDK targets Sae2 to control DNA-end resection and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
8. [Human SIRT6 promotes DNA end resection through CtIP deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
9. [The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
10. [EXD2 promotes homologous recombination by facilitating DNA end resection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
11. [N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
12. [SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
13. [Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
14. [CDK targets Sae2 to control DNA-end resection and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
15. [AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
16. [PALB2 is an integral component of the BRCA complex required for homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
17. [BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
18. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
19. [Characterization of a carboxy-terminal BRCA1 interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
20. [Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
21. [CtIP tetramer assembly is required for DNA-end resection and repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
22. [Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
23. [DNA end resection by CtIP and exonuclease 1 prevents genomic instability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
24. [LEDGF (p75) promotes DNA-end resection and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
25. [CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
26. [Human CtIP mediates cell cycle control of DNA end resection and double strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
27. [Human CtIP mediates cell cycle control of DNA end resection and double strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
29. [Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
30. [CtIP is required to initiate replication-dependent interstrand crosslink repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
32. [Human SIRT6 promotes DNA end resection through CtIP deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99708&geneProductId=UniProtKB:Q99708)
33. [CtIP is required to initiate replication-dependent interstrand crosslink repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708)
34. Ensembl Release 99